The R2Drive is a recoverable and reusable metal microdrive developed in the Buzsáki lab. It is part of a head-gear system for rats or mice.
Like our 3Drive, the R2Drive works with most commercial silicon probes with a flex cable, and can be made compatible with Neuropixels probes.
A major innovation is that the drive sits on an implantable base and can be removed from it after an experiment for reuse. This allows a probe mounted on the drive to be reused multiple times, resulting in significantly lower costs for experiments and less experimental interruptions due to silicon probe lead times.
In addition, a probe mounted on an R2Drive can easily be connected to a stereotax for acute recordings, allowing you to share probes between acute and chronic experiments.
Example publications using the R2Drive
Metal microdrive and head cap system for silicon probe recovery in freely moving rodent
( Vöröslakos et al., 2021, eLife)
- Species: Mice / Rats
Preconfigured dynamics in the hippocampus are guided by embryonic birthdate and rate of neurogenesis
(Huszár et al., 2022, Nature Neuroscience)
- Species: Mice
- Paradigm: Freely moving / behaving animals
- Silicon probe + optic fiber
Simultaneous Electrophysiology and Optogenetic Perturbation of the Same Neurons in Chronically Implanted Animals using μLED Silicon Probes
( Kinsky et al., 2023, bioRxiv)
- Species: Rats / Mice
- µLED silicon probes
Interictal epileptiform discharges affect memory in an Alzheimer’s Disease mouse model
(Soula et al., 2023, bioRxiv)
- Model system: AD transgenic mice